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Transporting bone marrow for in vitro purging before autologous reinfusion
W E Janssen1, A P Gee, J R Graham-Pole
1Department of Pediatrics, University of Florida, Gainesville 32610.
Progress in Clinical and Biological Research
|January 1, 1990
Summary
Bone marrow transportation to a central facility for processing is safe and effective. Studies show no difference in outcomes for transported versus non-transported marrow, ensuring patient safety in stem cell transplants.
Area of Science:
- Hematology
- Oncology
- Transplant Medicine
Background:
- Bone marrow transplantation is a critical treatment for neuroblastoma.
- Decentralized harvesting and central processing of bone marrow require reliable transport logistics.
Purpose of the Study:
- To evaluate the safety and efficacy of transporting bone marrow for processing.
- To establish standards for bone marrow transport in multi-center studies.
Main Methods:
- Bone marrow was harvested from 80 neuroblastoma patients across 16 North American centers.
- Marrow was transported on wet ice or cold packs via commercial carriers or aircraft to a central lab.
- Post-processed marrow was frozen in liquid nitrogen and returned to the referring institution.
Main Results:
- No significant differences were observed in CFU-GM recovery between transported and non-transported marrow.
- The fraction of viable cells at thawing remained consistent regardless of transport.
- Time to engraftment in patients was unaffected by the marrow transport process.
Conclusions:
- Transportation of harvested bone marrow to a central processing facility is a safe procedure.
- Established transport protocols ensure the integrity of bone marrow for transplantation.
- Standardized procedures are recommended for safe processing, shipping, and storage of bone marrow across all participating centers.
