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Related Experiment Video

Updated: May 17, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
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Ankylosing spondylitis and uveitis: overview.

Enéias Bezerra Gouveia1, Dório Elmann, Maira Saad de Ávila Morales

  • 1Faculdade de Medicina, Universidade de São Paulo, Brazil. ewazowzky@uol.com.br

Revista Brasileira De Reumatologia
|October 24, 2012
PubMed
Summary
This summary is machine-generated.

Ankylosing spondylitis, a chronic axial skeleton disease, often presents with acute anterior uveitis. Early diagnosis and collaborative care between ophthalmologists and rheumatologists improve patient outcomes.

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Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

  • Rheumatology and Ophthalmology
  • Inflammatory and Autoimmune Diseases

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease impacting the axial skeleton, leading to stiffness and functional limitations.
  • It typically emerges in the second to third decade of life, predominantly in HLA-B27-positive Caucasian males.
  • The exact etiology and pathogenesis remain unclear, complicating diagnosis.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, clinical features, diagnosis, and treatment of ankylosing spondylitis (AS).
  • To examine the association between ankylosing spondylitis and ocular changes, particularly acute anterior uveitis.
  • To emphasize the importance of interdisciplinary collaboration for patient management.

Main Methods:

  • Literature review using PubMed (MEDLINE), LILACS, and Ophthalmology Library databases.
  • Synthesis of epidemiological, clinical, and treatment data for ankylosing spondylitis.
  • Analysis of the prevalence and characteristics of ocular manifestations in AS patients.

Main Results:

  • Acute anterior uveitis is the most frequent extra-articular manifestation of AS, affecting 20%-30% of patients.
  • HLA-B27 antigen is present in about half of acute anterior uveitis cases associated with AS.
  • While diagnosis can be challenging, clinical control and treatment for AS are often satisfactory.

Conclusions:

  • Ophthalmologists and rheumatologists must collaborate for optimal assessment and treatment of uveitis in AS patients.
  • Acute anterior uveitis can be an initial sign of undiagnosed rheumatic disease, typically responding well to treatment.
  • Integrated care approaches are crucial for managing the complex interplay between AS and ocular conditions.