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Updated: May 17, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Immune disorders and its correlation with gut microbiome.
Ji-Sun Hwang1, Chang-Rok Im, Sin-Hyeog Im
1School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Korea.
Immune Network
|October 24, 2012
Summary
Probiotics, beneficial gut bacteria, can help manage allergic diseases like atopic dermatitis and asthma. The effectiveness of probiotics is strain-specific, requiring tailored use for different immune disorders.
Area of Science:
- Immunology
- Microbiology
- Allergology
Background:
- Allergic disorders, including atopic dermatitis and asthma, are prevalent in industrialized nations.
- Genetic, environmental, and gut microbiota factors contribute to atopic dermatitis development.
- The hygiene hypothesis suggests reduced microbial exposure increases allergy susceptibility.
Purpose of the Study:
- To review the diverse functions and regulatory mechanisms of probiotics in immune disorders.
- To highlight the strain-specific effects of probiotics in managing allergic diseases.
Main Methods:
- Review of existing human clinical trials and mouse studies on probiotics and immune disorders.
- Analysis of probiotic mechanisms, particularly immune response modulation in gut-associated lymphoid tissue (GALT).
Main Results:
- Probiotics, a type of symbiotic microorganism, offer health benefits through various mechanisms.
- Probiotics can modify immune responses within the gut-associated lymphoid tissue (GALT).
Conclusions:
- Probiotic efficacy in immune disorders is strain-dependent.
- Specific probiotic strains are necessary for targeting particular allergic diseases.
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