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Primary intracranial malignant lymphomas a fine structural cytochemical and CSF immunological study
Clinical Neurology and Neurosurgery
|January 1, 1979
Summary
Primary brain lymphomas, classified as immunoblastomas and immunocytomas, originate from B-cells. These tumors show distinct ultrastructural features and varied immunological profiles in cerebrospinal fluid (CSF).
Area of Science:
- Neuropathology
- Immunology
- Oncology
Background:
- Primary intracranial malignant lymphomas are rare and their cellular origin has been debated.
- Previous classifications included reticulum cell sarcomas and microgliomas.
Purpose of the Study:
- To investigate the ultrastructural and immunophenotypic characteristics of primary intracranial malignant lymphomas.
- To determine the cellular origin of these tumors.
Main Methods:
- Cytochemical and electron microscopy on six biopsy-confirmed cases.
- Cerebrospinal fluid (CSF) analysis including B-cell and IgG levels.
Main Results:
- Ultrastructural studies confirmed identity with extraneural immunoblastomas and immunocytomas.
- Evidence of B-cell differentiation from 'blast-like' cells was observed in all tumors.
- CSF studies revealed increased B cells, surface IgG, and monoclonal IgG/IgM in some cases, indicating heterogeneity.
Conclusions:
- Primary intracranial malignant lymphomas, specifically immunoblastomas and immunocytomas, are of B-cell origin.
- These lymphomas exhibit morphological and immunological heterogeneity.
- Findings support reclassifying these tumors based on their B-cell lineage.