Related Experiment Video
Updated: May 17, 2026

06:01
Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
Published on: July 26, 2024
Editorial: vasoactive intestinal peptide (vip): historic perspective and future potential
Endocrine, Metabolic & Immune Disorders Drug Targets
|October 26, 2012
Summary
Vasoactive intestinal peptide (VIP) inhibits inflammatory mediators in mammals. Research shows VIP
Area of Science:
- Immunology
- Neuroendocrinology
- Pharmacology
Background:
- Vasoactive intestinal peptide (VIP) has been recognized for its immunomodulatory functions since the 1970s.
- VIP plays a crucial role in regulating the immune system in mammals.
- Its effects span the production and action of various inflammatory mediators.
Discussion:
- This review explores the impact of VIP on immune cell function.
- It examines the therapeutic potential of VIP in preclinical models of human inflammatory diseases.
- The review introduces ongoing research areas within this specialized field.
Key Insights:
- VIP demonstrates a significant inhibitory effect on inflammatory mediators.
- Preclinical studies indicate promising therapeutic applications for VIP in inflammatory conditions.
- VIP's multifaceted role in immune regulation is a key area of focus.
Outlook:
- Further research into VIP's mechanisms of action is warranted.
- Clinical translation of VIP-based therapies for human inflammatory diseases is a future direction.
- Exploring VIP's potential in diverse inflammatory conditions remains an active research area.
More Related Videos
Related Concept Videos
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Enteric Nervous System: Regulation of GI Motor Activity
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
Physiology of the Gastrointestinal System II: Digestion and Absorption
The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Physiology of Enteric Nervous System and Gut Health
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...

