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Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
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Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression

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Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: May 17, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

[Depression and neurological diseases].

D Piber¹, K Hinkelmann, S M Gold

¹Klinik für Psychiatrie und Psychotherapie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Deutschland. dominique.piber@charite.de

|October 26, 2012

Summary

This summary is machine-generated.

Depression is a common comorbidity and risk factor in neurological diseases like stroke, Parkinson's, and MS. Understanding its impact is crucial for patient outcomes and quality of life.

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Last Updated: May 17, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

Neurology
Psychiatry

Context:

Depressive syndromes are frequently observed in patients with neurological diseases.
Depression can be a primary symptom or a significant comorbidity.
It impacts the course and prognosis of conditions like stroke, Parkinson's disease, multiple sclerosis, and epilepsy.

Purpose:

To review the epidemiological, pathophysiological, and therapeutic aspects of depression in neurological diseases.
To highlight depression's dual role as both a comorbidity and a risk factor.

Summary:

Approximately 40% of stroke patients develop depression, negatively affecting their recovery.
Depression is also identified as a significant risk factor for developing stroke.
The article examines depression's role in the progression and quality of life for various neurological conditions.

Impact:

Improved understanding of depression's role in neurological disorders can lead to better patient management.
Identifying depression as a risk factor may enable preventative strategies for neurological diseases.
This review provides a comprehensive overview for clinicians and researchers in neurology and psychiatry.