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Updated: May 17, 2026
09:52
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Immunotherapy for allergic fungal sinusitis.
Ashley G Hall1, Richard D deShazo
1Departments of Medicine and Pediatrics, Division of Clinical Immunology and Allergy, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Current Opinion in Allergy and Clinical Immunology
|October 26, 2012
Summary
Allergen immunotherapy for allergic fungal sinusitis (AFS) shows promise in reducing symptom recurrence and postoperative issues. Further controlled studies are needed to confirm its efficacy and optimal use in treatment regimens.
Area of Science:
- Immunology
- Otolaryngology
- Allergy
Background:
- Allergic fungal sinusitis (AFS) is an IgE-mediated hypersensitivity reaction to fungi in the paranasal sinuses.
- The exact pathogenesis of AFS is not fully understood.
- Fungal antigens are implicated in AFS development.
Purpose of the Study:
- To review the current literature on allergen immunotherapy for AFS.
- To evaluate the efficacy of fungal antigen immunotherapy as an adjunct treatment for AFS.
Main Methods:
- Literature review of published studies on allergen immunotherapy for AFS.
- Analysis of treatment outcomes, including symptom reduction and recurrence rates.
Main Results:
- Evidence suggests allergen immunotherapy for fungal allergens may effectively treat AFS symptoms.
- This therapy may decrease postoperative exacerbations and the need for further operations.
- No evidence indicates that this immunotherapy induces immune complex disease.
Conclusions:
- Allergen immunotherapy for fungi is a promising treatment to reduce AFS recurrence.
- It should be considered as part of the AFS treatment regimen.
- Controlled studies are essential due to small patient numbers and potential risks if administered before fungal clearance.
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