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Bone mineral density increases in HIV-infected children treated with long-term combination antiretroviral therapy

Madeleine J Bunders1, Olivier Frinking, Henriette J Scherpbier

  • 1Department of Paediatric Immunology, Haematology, and Infectious Diseases, Emma Children Hospital, Amsterdam, The Netherlands. m.j.bunders@amc.uva.nl

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 26, 2012
PubMed

Insights

Combination antiretroviral therapy (cART) for children with human immunodeficiency virus (HIV) may affect bone health. Long-term data reveal that cumulative cART positively impacts bone mineral density (BMD) over time in these children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Endocrinology

Background:

  • Long-term management of human immunodeficiency virus (HIV) in children involves combination antiretroviral therapy (cART).
  • Potential adverse effects of cART, including impacts on bone health, require ongoing evaluation.
  • Osteoporosis is a significant concern in HIV-infected populations.

Purpose of the Study:

  • To assess the long-term effects of combination antiretroviral therapy (cART) on bone mineral density (BMD) in children with HIV.
  • To evaluate the relationship between cumulative cART exposure and BMD changes over time.

Main Methods:

  • Longitudinal study design.
  • Collection and analysis of bone mineral density (BMD) data in HIV-infected children.
  • Assessment of cumulative combination antiretroviral therapy (cART) exposure.

Main Results:

  • Longitudinal data demonstrated a positive impact of cumulative cART on bone mineral density (BMD) over time.
  • Analysis indicated that extended treatment with cART is associated with improved BMD in HIV-infected children.

Conclusions:

  • Combination antiretroviral therapy (cART) appears to have a beneficial effect on bone mineral density (BMD) in children with HIV.
  • Long-term cART may mitigate some of the bone-related adverse effects in pediatric HIV infection.

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