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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

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Related Experiment Video

Updated: May 17, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Randomized controlled trials in bariatric surgery.

Chien-Pin Chan1, Bing-Yen Wang, Ching-Yuan Cheng

  • 1Bariatric Surgery and Diabetes Health Management Center, Changhua Christian Hospital and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Obesity Surgery
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

Randomized controlled trials (RCTs) in obesity surgery show a growing trend. While long-term data is limited, bariatric surgery appears more effective than medical treatment for morbid obesity.

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Area of Science:

  • Bariatric and Metabolic Surgery
  • Clinical Research Methodology

Background:

  • Obesity surgery literature has a gap in comprehensive reviews of randomized controlled trials (RCTs).
  • A 40-year review of RCTs is needed to understand the evolution and impact of obesity surgery research.

Purpose of the Study:

  • To systematically review and analyze all published RCTs in obesity surgery from 1972 to 2011.
  • To identify trends in research focus, publication patterns, and geographical contributions.

Main Methods:

  • A comprehensive literature search was conducted in the PubMed database using terms like "bariatric surgery" and "obesity surgery".
  • RCTs published in English between January 1972 and December 2011 were included, excluding basic science and anesthesia studies.
  • Eligible trials were categorized into intervention comparisons, surgical techniques, preoperative evaluation, and postoperative care.

Main Results:

  • 168 RCTs met the eligibility criteria out of 753 identified manuscripts.
  • The majority of trials focused on intervention comparisons (32%) and intraoperative techniques (48%).
  • There was a significant increase in RCT publications, with 70.8% published in the last decade of the study period (2002-2011).

Conclusions:

  • A notable trend of increasing RCTs in bariatric surgery research was observed.
  • Despite a lack of large, long-term, adequately powered studies, surgical interventions demonstrate greater efficacy than medical management for morbid obesity.