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Related Experiment Video

Updated: May 17, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
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Exploring PPAR modulation in experimental mice.

Anna Rull1, Gerard Aragonès, Raúl Beltrán-Debón

  • 1Unitat de Recerca Biomèdica(URB-CRB), Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

Choosing the right animal models is crucial for PPAR research. A comprehensive, multi-tissue

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Area of Science:

  • Pharmacology and Toxicology
  • Genetics and Molecular Biology

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are key regulators of metabolism.
  • PPAR modulation is studied in experimental animals, but results require cautious human interpretation.
  • Unexpected effects in human studies necessitate careful consideration of animal model relevance.

Purpose of the Study:

  • To highlight the challenges in translating PPAR research findings from animal models to humans.
  • To propose an improved research strategy for studying PPAR activation.

Main Methods:

  • Review of existing literature on PPAR research in animal models.
  • Consideration of human epidemiologic study outcomes.
  • Advocacy for a global approach utilizing omic technologies.

Main Results:

  • Animal models for PPAR research present interpretation challenges.
  • Human epidemiologic studies have shown unexpected effects of PPAR activation.
  • Omic technologies offer a more comprehensive approach to PPAR research.

Conclusions:

  • Cautious interpretation is needed when extrapolating animal PPAR study results to humans.
  • A global, multi-tissue omic approach is recommended for robust PPAR research.
  • Proper tissue preservation is essential for future PPAR-related assessments.