Isolation, Characterization and Biological evaluation of secondary metabolite from Aspergillus funiculosus

Screening of Aspergillus funiculosus for bioactive secondary metabolites produced kojic acid, which is know to have wide range of biological properties. It is very active against Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli, but moderately active against yeasts and Gram-positive bacteria except Staphylococcus epidermidis. Filamentous Fungi are more sensitive to kojic acid. When it exposed to larvicidal activity on Aedes aegypti third instar larvae are more sensitive than early fourth instar larvae.