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Updated: May 17, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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Lipid abnormalities in chronic renal failure.

R Bhagwat¹, S P Joshi, P Salgia

¹Department of Pathology, Choithram Hospital & Research Centre, Manik Bay Road, 452 001 Indore.

Indian Journal of Clinical Biochemistry : IJCB

|October 27, 2012

Summary

Chronic renal failure (CRF) patients exhibit uniform dyslipidemia, including high triglycerides and low HDL cholesterol, regardless of the cause. These lipid abnormalities may accelerate atherosclerosis and contribute to early mortality in CRF.

Keywords:

Atherogenesis Chronic Renal Failure (CRF)Dyslipidemia High Density Lipids (HDL)Low Desity Lipids (LDL)

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Last Updated: May 17, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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Published on: July 3, 2013

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Nephrology
Cardiology
Clinical Biochemistry

Background:

Lipid abnormalities are a significant contributor to premature mortality in patients with chronic renal failure (CRF).
Understanding the specific lipid profiles in CRF patients based on etiology is crucial for risk stratification and management.

Purpose of the Study:

To investigate the lipid profiles (total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) in patients with chronic renal failure (CRF).
To determine if dyslipidemia patterns in CRF vary based on the underlying causes of renal failure.
To assess the relationship between dyslipidemia and renal function markers like blood urea nitrogen and serum creatinine.

Main Methods:

114 CRF patients were categorized by the etiology of their renal failure.
Blood samples were analyzed for lipid parameters (total cholesterol, triglyceride, HDL, LDL) and renal function markers (BUN, creatinine).
A control group of 25 healthy individuals was included for comparison.

Main Results:

CRF patients demonstrated significantly elevated triglyceride levels (232 mg/dl) and markedly reduced HDL cholesterol levels (20 mg/dl) compared to controls (P<0.001).
LDL cholesterol levels showed a non-significant increase (104 mg/dl) in CRF patients compared to controls.
The observed dyslipidemia pattern was consistent across all etiological groups and independent of serum creatinine levels.

Conclusions:

CRF patients present with a uniform pattern of dyslipidemia, characterized by hypertriglyceridemia and low HDL cholesterol, irrespective of the cause of CRF.
This dyslipidemia is independent of the severity of renal impairment as indicated by serum creatinine levels.
While not the sole cause of mortality, these lipid abnormalities may play a role in accelerating atherogenesis, contributing to early mortality in CRF patients.