[Physiological and cytological bases of cellular regulation of angiogenesis]

One of the major directions of development of cell therapy is a therapeutic angiogenesis. Progress in this area is associated with the discovery of endothelial progenitor cells, which play an important role in neovascularization of adult tissues. The list of candidate cells for the regeneration of the cardiovascular system is constantly updated. Nevertheless, these preclinical and clinical studies to assess the possibility of using cells for therapy, isolated from different sources are contradictory. For urgent issues in the research of cell therapy include lack of uniform nomenclature, as well as the lack of functional characteristics expected of stem/progenitor cells. Given the controversial results of initial clinical trials, require more accurate knowledge of the biological properties of cells used for transplantation.