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Elevated plasma histamine levels in systemic sclerosis (scleroderma).

V Falanga1, N A Soter, R D Altman

  • 1Department of Dermatology, University of Miami, Fla.

Archives of Dermatology
|March 1, 1990
PubMed
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Elevated plasma histamine levels were found in over half of systemic sclerosis patients, particularly those with diffuse disease, suggesting histamine may contribute to fibrosis in this condition.

Area of Science:

  • Rheumatology
  • Dermatology
  • Fibrosis Research

Background:

  • Systemic sclerosis involves excessive collagen deposition in skin and organs.
  • Fibroblast stimulation by blood or inflammatory factors is a proposed mechanism.
  • Mast cells and histamine are implicated as potential mediators of fibrosis.

Purpose of the Study:

  • To investigate plasma histamine levels in patients with systemic sclerosis.
  • To determine the correlation between histamine levels and disease subtype (diffuse vs. limited).

Main Methods:

  • Plasma histamine levels were measured in 32 systemic sclerosis patients.
  • Patients were categorized by disease subtype and clinical activity.

Main Results:

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  • Elevated plasma histamine levels were observed in 56% of patients.
  • Higher prevalence of elevated histamine in diffuse systemic sclerosis (74%) compared to limited (31%).
  • No correlation found between histamine levels, clinical activity, or disease duration.

Conclusions:

  • Histamine may play a role in the fibrotic process of systemic sclerosis.
  • Elevated histamine is more frequent in diffuse systemic sclerosis.
  • Further research is warranted to explore histamine's role in scleroderma pathogenesis.