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Updated: May 17, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Endocrine and metabolic changes during sepsis: an update.

Romesh Khardori¹, Danielle Castillo

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, Strelitz Diabetes Institute for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA 23510, USA. khardoRK@evms.edu

The Medical Clinics of North America

|October 30, 2012

Summary

Infectious disease specialists should understand endocrine and metabolic changes caused by medications. Collaboration with endocrinologists improves patient care and outcomes.

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Area of Science:

Endocrinology
Metabolic Medicine
Infectious Diseases

Background:

Endocrine and metabolic abnormalities are common in critically ill patients.
These issues are typically managed by endocrinologists and intensivists.
Infectious disease specialists' pharmacologic interventions can precipitate these changes.

Purpose of the Study:

To review endocrine and metabolic changes associated with infectious diseases and their treatments.
To provide explanations for observed metabolic perturbations.
To emphasize the importance of interdisciplinary communication.

Main Methods:

Literature review of recent and relevant studies.
Analysis of endocrine and metabolic alterations.
Synthesis of information regarding drug-induced abnormalities.

Main Results:

Identification of significant endocrine and metabolic changes.
Elucidation of potential mechanisms underlying these perturbations.
Recognition of the impact of medications used in infectious disease management.

Conclusions:

Infectious disease specialists must be aware of the endocrine and metabolic consequences of their treatments.
Enhanced dialogue between infectious disease specialists, endocrinologists, and intensivists is crucial.
Improved interdisciplinary collaboration leads to better patient outcomes.