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Updated: May 17, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention
Binita Shah1, Brandon Oberweis, Lakshmi Tummala
1Division of Cardiology, Department of Medicine, New York University School of Medicine and Veterans Affairs New York Harbor Health Care System, New York, New York, USA.
Insights
Baseline mean platelet volume (MPV) does not predict long-term mortality after percutaneous coronary intervention (PCI). However, an increasing MPV over time post-PCI is linked to significantly higher mortality risk in these patients.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Interventional Cardiology
Background:
- Increased platelet activity is a known risk factor for adverse cardiovascular events.
- Mean platelet volume (MPV) is a marker of platelet activation and size.
- The relationship between baseline MPV and long-term mortality after percutaneous coronary intervention (PCI) is not well-established, and the impact of MPV changes over time remains unevaluated.
Purpose of the Study:
- To investigate the association between baseline MPV and long-term mortality in patients undergoing PCI.
- To evaluate the impact of changes in MPV over time on long-term mortality following PCI.
Main Methods:
- A cohort of 1,512 patients undergoing PCI had their MPV measured at multiple time points (baseline, 30 days, 60 days, 90 days, 1, 2, and 3 years).
- The speed of MPV change was estimated using linear regression.
- Long-term mortality was tracked via the Social Security Death Index over a median follow-up of 8.7 years.
Main Results:
- No significant difference in long-term mortality was observed when patients were stratified by baseline MPV quartiles (p = 0.74).
- Among 839 patients with available longitudinal MPV data, overall mortality was 49.1%.
- Mortality was significantly higher in patients experiencing an increase in MPV over time (52.9%) compared to those with a decrease (44.2%) or no change (49.1%) (p < 0.0001).
Conclusions:
- Baseline MPV is not associated with long-term mortality in patients after PCI.
- An increase in MPV over time following PCI is significantly associated with increased long-term mortality.
- Monitoring MPV trends after coronary revascularization may offer value in patient risk stratification.
Abstract:
Increased platelet activity is associated with adverse cardiovascular events. The mean platelet volume (MPV) correlates with platelet activity; however, the relation between the MPV and long-term mortality in patients undergoing percutaneous coronary intervention (PCI) is not well established. Furthermore, the role of change in the MPV over time has not been previously evaluated. We evaluated the MPV at baseline, 30 days, 60 days, 90 days, 1 year, 2 years, and 3 years after the procedure in 1,512 patients who underwent PCI. The speed of change in the MPV was estimated using the slope of linear regression. Mortality was determined by query of the Social Security Death Index. During a median of 8.7 years, mortality was 49.3% after PCI. No significant difference was seen in mortality when stratified by MPV quartile (first quartile, 50.1%; second quartile, 47.7%; third quartile, 51.3%; fourth quartile, 48.3%; p = 0.74). For the 839 patients with available data to determine a change in the MPV over time after PCI, mortality was 49.1% and was significantly greater in patients with an increase (52.9%) than in those with a decrease (44.2%) or no change (49.1%) in the MPV over time (p <0.0001). In conclusion, no association was found between the baseline MPV and long-term mortality in patients undergoing PCI. However, increased mortality was found when the MPV increased over time after PCI. Monitoring the MPV after coronary revascularization might play a role in risk stratification.
