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Updated: May 17, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
[Roles of Wnt signaling in bone metabolism]
1Institute for Oral Science, Matsumoto Dental University, Japan.
Abstract:
Wnts, palmitoylated and glycosylated molecules play a central role in the early development of organs and tissues. Wnts bind to receptor complexes of frizzled and low density lipoprotein-related protein 5/6, which in turn, activate theβ-catenin-dependent canonical pathway. Wnt5a, a typical non-canonical ligand, activates theβ-catenin-independent noncanonical pathways such as the Wnt/Ca pathway and the Wnt/planar cell polarity pathway. Recent studies have established that Wnt-mediated signals are crucial for bone formation and resorption. This review summarizes the current knowledge of the roles of Wnt signaling in bone formation and resorption.
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