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Updated: May 17, 2026

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
Published on: January 2, 2016
EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear
Elaine Y M Wong1, Mohi Ahmed, Pin-Xian Xu
1Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA. Elaine.wong@mssm.edu
Abstract:
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.
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