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Updated: May 17, 2026

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A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments
Published on: October 2, 2012
Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity
Stephen G Bell1, James H C McMillan, Jake A Yorke
1The School of Chemistry and Physics, The University of Adelaide, SA, Australia. stephen.bell@adelaide.edu.au
Abstract:
A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known.

