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Updated: May 17, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Efficiency of biolistic DNA vaccination in experimental type I allergy
Verena Raker1, Joachim Maxeiner, Angelika B Reske-Kunz
1Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. rakerv@uni-mainz.de
Abstract:
Gene gun-mediated delivery of allergen-encoding plasmid DNA has been in focus for many years now as being a needle-free alternative to the protein-based desensitization regimen used in specific immunotherapy. Biolistic immunization with the Helios gene gun has proven to be potent in the induction of antigen-specific CD4(+) and CD8(+) T cells. Here we describe biolistic vaccination in experimental mouse models of IgE-mediated type I allergy as well as allergen-induced airway inflammation.
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