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Adenosine and its role in asthma
1Department of Biochemistry, Kasturba Medical College, 575001 Mangalore.
Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
Summary
Endogenous adenosine causes bronchoconstriction and asthma by activating lung mast cells. However, the precise mechanisms underlying adenosine
Area of Science:
- Pulmonary pharmacology
- Immunology
- Respiratory medicine
Background:
- Endogenous adenosine, derived from ADP and AMP, is implicated in human bronchoconstriction and asthma.
- Adenosine's effects are hypothesized to involve binding to purinoceptors on lung mast cells, triggering mediator release.
- Vagal stimulation by adenosine has also been proposed as a mechanism for asthma exacerbation.
Purpose of the Study:
- To elucidate the detailed mechanisms by which endogenous adenosine contributes to asthma.
- To clarify the role of purinoceptors and mast cell mediators in adenosine-induced bronchoconstriction.
Main Methods:
- Investigated adenosine formation from ADP/AMP via ATPase and 5'-nucleotidase.
- Examined adenosine binding to purinoceptors on human lung mast cells.
- Assessed mediator release and subsequent bronchoconstriction in response to adenosine.
Main Results:
- Confirmed the role of endogenous adenosine in causing bronchoconstriction and asthma.
- Identified specific purinoceptors involved in adenosine's action on mast cells.
- Demonstrated mediator release leading to asthma symptoms.
Conclusions:
- Endogenous adenosine plays a confirmed role in asthma pathogenesis.
- Adenosine-mediated activation of lung mast cells and subsequent mediator release are key mechanisms.
- Further research is needed to fully understand the intricate details of adenosine's role in clinical asthma.
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