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Lack of precision in HbA(1c) values on variant II in cases of hemoglobin Q India

P K Nigam1, S Sharma, R Sareen

  • 1Dr Lal PathLabs Pvt Ltd, 'ESKAY HOUSE', 54, Hanuman Road, 110001 New Delhi, India.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

This study was carried out to check the precision of HbA(1c) values on Bio-Rad Variant II in cases of a rare hemoglobin variant Q India. The study was carried out over a three month period on samples collected for HbA(1c) estimation. Seven out of eleven patients showed variable results of HbA(1c) with a very high and unacceptable intraday mean coefficient of variation (CV) of 9.93%. We conclude, that the results of HbA(1c) on Variant II can not be reported without adversely affecting HbA(1c) as a marker of long-term glycemic control in patients who have hemoglobin Q India. The HbA(1c) value of these patients needs to be assessed by a different instrument/method or the glycemic control be monitored by an alternate test like serum Fructosamine.

Keywords:
HbA1cdiabetes mellitusprecisionvariant hemoglobin

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