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Updated: May 17, 2026
Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
Published on: June 28, 2024
Blood glutathione levels in head and neck malignancies
Y P Singh1, O P Sachdeva, S K Aggarwal
1Department of Biochemistry, Pt.B.D. Sharma PostGraduate Institute of Medical Sciences, Rohtak, Haryana India ; Department of ENT, Pt.B.D. Sharma PostGraduate Institute of Medical Sciences, Rohtak, Haryana India.
Abstract:
Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18-76 years and the results were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and neck cancer have increased oxidative stress.
