Related Experiment Video
Updated: May 17, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia
Pallab Basu1, Sabyasachi Som, Nabendu Choudhuri
1Department of Biochemistry, Burdwan Medical College and Hospital, Burdwan, 713104 West Bengal India.
Abstract:
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients, a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = -0.857, P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of asphyxia by Apgar score.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Serum Studies: Renal Function Tests
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Acute Kidney Injury IV: Diagnostic Studies and Prevention