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Biochemical and genetic studies on cardiometabolic syndrome

A Supriya Simon1, D Dinesh Roy, V Jayapal

  • 1Department of Biochemistry, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, 689 101 India.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

Patients with cardiometabolic syndrome exhibit higher DNA damage, indicated by increased Cytokinesis-block micronuclei (CBMN) frequency. This DNA damage is linked to factors like dyslipidemia and glucose intolerance, common in metabolic syndrome.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Cardiometabolic syndrome is a significant global health concern.
  • It is characterized by a cluster of clinical conditions.
  • Coronary artery disease (CAD) often coexists with cardiometabolic syndrome.

Purpose of the Study:

  • To investigate DNA damage in patients with CAD and cardiometabolic syndrome.
  • To compare DNA damage levels between patients and healthy controls.
  • To explore the association between risk factors and DNA damage.

Main Methods:

  • Selected 72 patients with CAD and cardiometabolic syndrome and 40 healthy controls.
  • Collected clinical, epidemiological, and anthropometric data.
  • Performed lipid profile analysis and Cytokinesis-block micronuclei (CBMN) assay.

Main Results:

  • Patients showed significantly higher total cholesterol, triglyceride, and LDL-cholesterol.
  • Patients had significantly lower HDL cholesterol compared to controls.
  • CBMN frequency was significantly higher in patients across all age groups.

Conclusions:

  • Patients with cardiometabolic syndrome exhibit elevated DNA damage.
  • This damage may result from free radical generation linked to lifestyle factors and aging.
  • Further research into free radical pathways is warranted.

Keywords:
Cardiometabolic syndromeCoronary artery diseaseCytokinesis-block micronuclei assayDNA damageLipid profileMetabolic syndrome

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