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Updated: May 17, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Clinical Inquiry: Can calcium supplements cause serious adverse effects in healthy people?
Hayam K Shaker1, Sue Stigleman
1Hendersonville Family Practice Residency Program, Mountain Area Health Education Center, Hendersonville, NC, USA. vijayzawar@yahoo.com
Abstract:
Yes, according to studies with some limitations. Calcium supplements with or without vitamin D increase the risk of myocardial infarction, with numbers needed to harm (NNH) over 5 years of 69 to 240 (strength of recommendation: B, meta-analyses of randomized controlled trials that evaluated a predominantly older female population and were limited by study designs).
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