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Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation

Irina Koryakina1, Gavin J Williams

  • 1Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA.

Chembiochem : a European Journal of Chemical Biology
|October 30, 2012
PubMed
Summary

Researchers engineered mutant malonyl-CoA synthetases with significantly altered substrate specificity using structure-guided mutagenesis and screening. These modified enzymes serve as valuable tools for studying polyketide synthase activity.

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