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Updated: Aug 14, 2026
06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Deep Eutectic Solvent-Assisted Synergistic Technologies for the Extraction of Natural Bioactive Compounds:
Wenrong Meng1, Wenhao Hu1, Tiancheng Sheng1
1School of Food Science and Technology, Shenyang Normal University, Shenyang 110031, China.
Foods (Basel, Switzerland)
|August 13, 2026
Summary
Deep eutectic solvents (DESs) are green extraction solvents, but their high viscosity is a challenge. This review unifies DESs with ultrasound, microwave, and enzymatic methods to enhance extraction of natural compounds.
Area of Science:
- Green chemistry and sustainable extraction technologies.
- Exploration of novel solvent systems for natural product isolation.
Background:
- Deep eutectic solvents (DESs) offer environmental benefits over traditional organic solvents for extracting bioactive compounds.
- High viscosity of DESs impedes mass transfer, limiting their practical application.
- Existing reviews focus on single auxiliary techniques, lacking a holistic approach.
Purpose of the Study:
- To integrate and critically compare DESs combined with ultrasound, microwave, enzymatic assistance, and hybrid systems.
- To elucidate the enhancement mechanisms and industrial feasibility of these integrated extraction technologies.
- To provide a comprehensive framework for optimizing DES-based extraction.
Main Methods:
- Systematic review of literature on DESs combined with auxiliary extraction techniques.
- Analysis of non-covalent interactions guiding DES component selection (HBA/HBD).
- Examination of synergistic mechanisms (viscosity reduction, cell disruption) of ultrasound, microwave, and enzymes.
Main Results:
- DESs combined with auxiliary techniques significantly enhance extraction efficiency of natural compounds.
- Ultrasound, microwave, and enzymatic assistance offer distinct synergistic benefits.
- Successful applications demonstrated for polyphenols, alkaloids, terpenoids, and polysaccharides.
Conclusions:
- Integrated DES systems offer a powerful approach for efficient natural product extraction.
- Addressing scale-up challenges (solvent recovery, equipment) is crucial for industrial adoption.
- Future directions include intelligent solvent design and continuous processing for sustainable extraction.
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