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Updated: May 17, 2026

In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion
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Published on: February 9, 2024

Sensitization induces hypersensitivity in trigeminal nerve.

X Wang1, H Liang, C Zhou

  • 1Department of Neurosurgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|October 31, 2012
PubMed
Summary
This summary is machine-generated.

Allergic inflammation increases 5-HT receptor 3 (R3) in trigeminal nerves, causing pain in trigeminal neuralgia. Targeting this receptor may offer new treatments for this chronic pain condition.

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Last Updated: May 17, 2026

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Area of Science:

  • Neuroscience
  • Immunology
  • Pain Research

Background:

  • Trigeminal neuralgia is a chronic neuropathic pain with unclear etiology.
  • Chronic inflammation is a proposed factor in trigeminal neuralgia pathogenesis.
  • This study investigates the role of allergic inflammation in trigeminal neuralgia.

Purpose of the Study:

  • To assess the role of allergic inflammation in the pathological status of trigeminal neuralgia.
  • To investigate the expression of 5-HT receptor 3 (R3) and mast cell involvement.
  • To determine the impact on trigeminal nerve hyperalgesia.

Main Methods:

  • Allergic inflammation was induced in rat infraorbital skin.
  • Immunohistochemistry was used to observe 5-HT R3 expression and mastocytosis.
  • Mechanical hyperalgesia was measured via head-withdrawal thresholds.

Main Results:

  • Sensitization increased 5-HT R3 expression and mast cell frequency in trigeminal nerves.
  • Exogenous 5-HT application also elevated 5-HT R3 expression.
  • Sensitized rats showed significantly lower mechanical allodynia thresholds, reversible with antagonists or stabilizers.

Conclusions:

  • Allergic inflammation induces 5-HT R3 overexpression in trigeminal nerves, leading to hyperalgesia.
  • 5-HT receptor 3 (R3) is implicated in trigeminal neuralgia pathogenesis.
  • 5-HT R3 presents a potential therapeutic target for trigeminal neuralgia treatment.