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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics -

Simon M Cook1, Amanda Skora, Christine M Gillen

  • 1Illawarra Health and Medical Research Institute, School of Biological Sciences, University of Wollongong, Wollongong, Australia.

Molecular Microbiology
|October 31, 2012
PubMed
Summary

Streptococcus pyogenes streptokinase variants exhibit distinct plasminogen activation pathways. Type-2b variants show reduced virulence, impacting the pathogenesis of group A Streptococcus infections.

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