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Updated: May 17, 2026
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate
Laura Rubió1, Alba Macià, Rosa M Valls
1Food Technology Department, XaRTA-TPV, Escola Tecnica Superior d'Enginyeria Agrària, Universitat de Lleida, University of Lleida, Alcalde Rovira Roure 191, 25198 Lleida, Spain.
Abstract:
We report progress in the study of olive oil phenolic metabolites in humans and identify a new hydroxytyrosol metabolite called hydroxytyrosol acetate sulphate, which was determined using tandem MS, after ingestion of 30 ml of olive oil with a high phenolic content (500 mg/kg oil), reaching a maximum concentration of 1.63 μM. In order to understand and explain the generation of this metabolite, two different pathways are proposed.
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