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Updated: May 17, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Analysis of peptide secondary structures by photoactivatable amino acid analogues
Knut Kölbel1, Christian H Ihling, Andrea Sinz
1Pharmaceutical Chemistry and Bioanalytics, Martin-Luther-Universität Halle-Wittenberg, Institut für Pharmazie, Wolfgang-Langenbeck-Strasse 4, 06108 Halle, Germany. knut.koelbel@pharmazie.uni-halle.de
Abstract:
Photochemical cross-linking was applied to trap intramolecular interactions in peptides. The incorporation of diazirine-labeled amino acid analogues in combination with high-resolution mass spectrometry made it possible to catch reverse-turn conformations within peptides, exactly map their self-interacting surfaces, and discriminate between stable and transient interactions.
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