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Updated: May 17, 2026
02:28
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Trends in lipid profiles in patients with psoriasis: a population-based analysis
Bharath Manu Akkara Veetil1, Eric L Matteson, Hilal Maradit-Kremers
1Division of Rheumatology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
BMC Dermatology
|November 1, 2012
Summary
Psoriasis onset is linked to decreasing total cholesterol and LDL, but rising triglycerides and falling HDL. These lipid changes occur before diagnosis and warrant further investigation beyond lipid-lowering treatments.
Area of Science:
- Dermatology
- Cardiovascular Health
- Metabolic Syndrome
Background:
- Psoriasis is linked to an atherogenic lipid profile.
- Longitudinal lipid changes preceding psoriasis onset are not well understood.
Purpose of the Study:
- To investigate the impact of psoriasis onset on serum lipid profiles.
- To analyze lipid trends in the five years before and after disease incidence.
Main Methods:
- A population-based cohort study compared 689 psoriasis patients with 717 non-psoriasis controls.
- Lipid profiles were analyzed five years pre- and post-psoriasis incidence.
- Random-effects models adjusted for age, sex, and calendar year.
Main Results:
- Both groups showed declining total cholesterol (TC) and LDL; non-psoriasis group had greater declines.
- Psoriasis patients exhibited increasing HDL and higher triglycerides (TG) pre-diagnosis.
- Psoriasis patients had significantly higher TG and lower HDL compared to controls.
Conclusions:
- Psoriasis patients experienced decreasing TC and LDL before disease onset.
- Elevated TG and reduced HDL were observed in the years preceding psoriasis diagnosis.
- Observed lipid alterations suggest factors beyond lipid-lowering therapy require study.
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