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Evidence for natural recombination between mink enteritis virus and canine parvovirus

Jianke Wang1, Shipeng Cheng, Li Yi

  • 1State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 4899 Juye Street, Changchun, 130112, China.

Virology Journal
|November 1, 2012
PubMed

Insights

Researchers discovered a novel mink enteritis virus (MEV) strain in China. This MEV strain shows genetic recombination with canine parvovirus (CPV), indicating a new evolutionary pathway for feline parvoviruses.

Area of Science:

  • Virology
  • Molecular Biology
  • Genetics

Background:

  • Mink enteritis virus (MEV) causes significant disease in mink populations.
  • Understanding the genetic diversity and evolution of MEV is crucial for disease control.

Purpose of the Study:

  • To isolate and characterize a novel MEV strain from diseased mink in China.
  • To investigate the genetic makeup and evolutionary origins of the isolated MEV strain.
  • To determine if recombination events have occurred between MEV and other parvoviruses.

Main Methods:

  • Virus isolation and identification using cell culture, hemagglutination assays, and electron microscopy.
  • Whole-genome sequencing of the isolated mink enteritis virus.
  • Phylogenetic and recombination analyses to compare the viral genome with known parvoviruses.

Main Results:

  • A novel MEV strain, MEV/LN-10, was successfully isolated and identified from mink with enteritis.
  • Genomic analysis revealed evidence of recombination between MEV and canine parvovirus (CPV).
  • Specifically, the NS1 gene originated from CPV, while the VP1 gene was of MEV origin.

Conclusions:

  • This study presents the first evidence of natural recombination between MEV and CPV.
  • Recombination is identified as a significant mechanism driving the genetic variation and evolution of MEV.
  • Heterogeneous recombination is demonstrated to occur within the feline parvovirus subspecies.

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