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Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
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Default mode network connectivity encodes clinical pain: an arterial spin labeling study

Marco L Loggia1, Jieun Kim, Randy L Gollub

  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School (HMS), Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, HMS, Boston, MA, USA MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA Program in Placebo Studies & the Therapeutic Encounter, Beth Israel Deaconess Medical Center, HMS, Boston, MA, USA Department of Psychiatry, Brigham and Women's Hospital, HMS, Boston, MA, USA.

Pain
|November 1, 2012
PubMed
Summary

Resting brain connectivity, particularly within the default mode network (DMN), shows promise as a biomarker for chronic pain. Changes in DMN connectivity correlate with pain intensity and predict responses to pain-inducing maneuvers in chronic low back pain patients.

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