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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Nutrigenomics and nutrigenetics.
Dd Farhud1, M Zarif Yeganeh, M Zarif Yeganeh
1School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iranian Journal of Public Health
|November 1, 2012
Summary
Nutritional genomics explores how nutrients interact with our genes. Understanding nutrigenetics and nutrigenomics can personalize diets for optimal health and disease prevention.
Area of Science:
- Nutritional Science
- Genetics
- Molecular Biology
Background:
- Nutrients interact with molecular mechanisms, modulating physiological functions.
- Nutritional genomics encompasses nutrigenetics and nutrigenomics, studying bioactive food components and the genome.
- Genetic variations influence food tolerances, dietary needs, and personalized nutrition.
Purpose of the Study:
- To explore the interaction between bioactive food components and the genome.
- To understand how nutrients influence gene expression (nutrigenomics) and how gene variants respond to nutrients (nutrigenetics).
- To highlight the potential for individualizing nutritional intake based on an individual's genome for health and disease prevention.
Main Methods:
- Investigating the molecular mechanisms of nutrient-gene interactions.
- Analyzing how genetic profiles affect the body's response to bioactive food components.
- Examining the impact of dietary components on gene expression and structure.
Main Results:
- Nutrigenomics explains how dietary components affect health by altering gene expression and structure.
- Nutrigenetics demonstrates that genetic profiles influence the absorption, metabolism, and action of food components.
- Gene-nutrient interactions offer insights into optimizing individual health and preventing diseases.
Conclusions:
- Personalized diets based on specific genotypes can optimize individual health.
- Understanding gene-nutrient interactions is crucial for the nutritional treatment of genome instability.
- Tailoring nutrition to an individual's genetic makeup can prevent the conversion of healthy phenotypes to diseases.
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