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Related Concept Videos

Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Reversible or Opposing Reactions01:26

Reversible or Opposing Reactions

Reversible or opposing reactions play a crucial role in understanding the dynamic nature of chemical processes. While kinetics focuses on how reactions proceed, thermodynamics emphasizes that most reactions do not reach completion. Instead, a reverse reaction starts occurring over time, and when its rate equals that of the forward reaction, a dynamic equilibrium is established.For example, consider a simple chemical process where A forms B reversibly. The rate constants for the forward and...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...

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Correction: Single-Stage Revision for Treatment of Prosthetic Joint Infection in Total Hip Arthroplasty.

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Related Experiment Video

Updated: May 17, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Published on: March 1, 2015

Single stage revision: regaining momentum.

S Gulhane1, I S Vanhegan, F S Haddad

  • 1University College London Hospitals, Department of Trauma & Orthopaedic Surgery, 235 Euston Road, London NW1 2BU, UK.

The Journal of Bone and Joint Surgery. British Volume
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

This study advocates for single-stage revision surgery for infected knee arthroplasty. This approach aims to improve outcomes for patients experiencing knee joint replacement infections.

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Last Updated: May 17, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

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Published on: March 1, 2015

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases

Background:

  • Infected knee arthroplasty presents a significant challenge in orthopedic surgery.
  • Current treatment options often involve multiple surgical procedures.

Purpose of the Study:

  • To present the rationale and evidence supporting single-stage revision for infected knee arthroplasty.
  • To advocate for this approach as a viable alternative to multi-stage protocols.

Main Methods:

  • Review of existing literature on infected knee arthroplasty management.
  • Analysis of outcomes associated with single-stage revision procedures.

Main Results:

  • Single-stage revision can achieve successful infection eradication and joint function restoration.
  • This method may reduce patient morbidity and healthcare costs compared to multi-stage options.

Conclusions:

  • Single-stage revision is a feasible and effective treatment for infected knee arthroplasty.
  • Further research and clinical adoption of this approach are warranted.