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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Tracking regional tissue volume and function change in lung using image registration.

Kunlin Cao1, Gary E Christensen, Kai Ding

  • 1GE Global Research, Niskayuna, NY 12309, USA.

International Journal of Biomedical Imaging
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

Bronchoalveolar lavage (BAL) fluid redistribution and reabsorption in the lungs were tracked using CT scans. Lung function changes correlated with fluid presence, returning to baseline as BAL fluid was absorbed.

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Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Respiratory Physiology

Background:

  • Bronchoalveolar lavage (BAL) fluid is delivered to the lungs during bronchoscopic procedures.
  • Previous studies demonstrated the 24-hour redistribution and reabsorption of BAL fluid in normal volunteers.
  • Understanding fluid dynamics and its impact on lung function is crucial.

Purpose of the Study:

  • To correlate bronchoalveolar lavage fluid redistribution and reabsorption with regional lung function changes.
  • To quantitatively assess BAL fluid volume and its impact on lung tissue.
  • To evaluate the time course of BAL fluid absorption and its effect on local lung function.

Main Methods:

  • Utilized lung CT datasets from six human subjects scanned at four time points.
  • Employed image-matching and registration procedures to align images across different time points and inflation levels.
  • Analyzed dense displacement fields to track tissue volume changes and quantify parenchymal deformation.

Main Results:

  • Quantitative fluid volume assessment showed good agreement with bronchoscopist-reported unretrieved BAL volume (R²=0.81).
  • Average lung tissue volume difference was ~2% after 24 hours, indicating near-complete fluid absorption.
  • Regional lung function changes were correlated with BAL fluid presence and resolved upon fluid reabsorption.

Conclusions:

  • Image-matching techniques effectively track BAL fluid dynamics and correlate them with regional lung function.
  • BAL fluid is significantly reabsorbed within 24 hours, with minimal residual volume.
  • Regional lung function is dynamically affected by BAL fluid presence and recovers as the fluid is absorbed.