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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Association of chronic kidney disease and peripheral artery disease with inappropriate left ventricular mass

Ho-Ming Su1, Tsung-Hsien Lin, Po-Chao Hsu

  • 1Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Plos One
|November 3, 2012
PubMed

Insights

Chronic kidney disease (CKD) and peripheral artery disease (PAD) are independently linked to abnormal left ventricular mass index (LVM) in patients. These conditions also show an additive effect on LVM, suggesting combined risk assessment is crucial.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Inappropriate left ventricular mass index (LVM) is linked to hemodynamic and metabolic changes.
  • Peripheral artery disease (PAD), indicated by abnormal ankle-brachial index (ABI), and chronic kidney disease (CKD) are common in patients.
  • A potential cause-effect relationship exists between CKD, PAD, and inappropriate LVM.

Purpose of the Study:

  • To investigate the independent and additive association of CKD and abnormal ABI with inappropriate LVM.
  • To assess the combined impact of reduced estimated glomerular filtration rate (eGFR) and PAD on LVM.

Main Methods:

  • A study included 1110 patients.
  • Inappropriate LVM was defined as observed LVM >28% of predicted value.
  • PAD was defined by ABI <0.9 or >1.3. Multivariate analysis was used.

Main Results:

  • Reduced eGFR (<45 ml/min/1.73 m²) and PAD were independently associated with inappropriate LVM (OR 1.644 and 2.082, respectively).
  • A significant interaction was found between reduced eGFR and PAD concerning inappropriate LVM (P=0.044).
  • Both reduced eGFR and PAD significantly correlated with observed/predicted LVM.

Conclusions:

  • Reduced eGFR and PAD are independently and additively associated with inappropriate LVM.
  • Assessing eGFR and ABI can help identify patients at risk for inappropriate LVM.
  • Findings highlight the cardiovascular burden in CKD patients with PAD.

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