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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Two cases of diffuse duodenitis associated with ulcerative colitis.

Katsuya Endo1, Masatake Kuroha, Hisashi Shiga

  • 1Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan.

Case Reports in Gastrointestinal Medicine
|November 3, 2012
PubMed
Summary

This study reports two rare cases of diffuse duodenitis in patients with ulcerative colitis (UC). These findings suggest the upper gastrointestinal tract may be involved in UC, warranting further investigation.

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research

Background:

  • Ulcerative colitis (UC) primarily affects the colon, with upper gastrointestinal involvement being uncommon.
  • Previous reports indicate rare instances of upper GI tract involvement in UC patients.

Purpose of the Study:

  • To present two unique cases of diffuse duodenitis associated with pancolonic UC.
  • To highlight the potential for upper GI tract involvement in UC pathogenesis.

Main Methods:

  • Case report of two patients with pancolonic UC and diffuse duodenitis.
  • Endoscopic and histological examination of duodenal lesions.
  • Exclusion of Helicobacter pylori and Crohn's disease.

Main Results:

  • Two patients with pancolonic UC presented with Helicobacter pylori-negative diffuse duodenitis.
  • Endoscopic and histological findings of duodenitis mimicked UC colonic lesions.
  • Both patients responded well to UC-specific treatments (mesalazine and prednisolone).

Conclusions:

  • Diffuse duodenitis can occur in patients with ulcerative colitis.
  • UC-associated duodenitis shares endoscopic and histological similarities with colonic UC lesions.
  • Further research is needed to determine if the upper GI tract is a target organ in UC.