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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Rhinocerebral invasive aspergillosis
1Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Abstract:
Here we present 10 cases of rhinocerebral aspergillosis. In this study we included only invasive type of cases. In 4 of these disease had extended into the brain parenchyma and in remaining cases diseases had extended intracranially but dura was not invaded. Details about the operative procedure and followup is presented. Till date only 3 of these cases are surviving.
Insights
This study details 10 invasive rhinocerebral aspergillosis cases. Survival was low, with only 3 patients alive, highlighting the disease
Area of Science:
- Mycology
- Infectious Diseases
- Neurosurgery
Background:
- Rhinocerebral aspergillosis is a severe fungal infection affecting the nasal passages and brain.
- Invasive forms pose significant challenges due to rapid progression and high mortality.
Purpose of the Study:
- To present a case series of invasive rhinocerebral aspergillosis.
- To analyze the clinical course, surgical management, and outcomes of affected patients.
Main Methods:
- Retrospective review of 10 patients diagnosed with invasive rhinocerebral aspergillosis.
- Documentation of disease extension (intracranial vs. parenchymal invasion).
- Details of surgical interventions and patient follow-up were recorded.
Main Results:
- Four cases involved brain parenchyma invasion; six had intracranial extension without dural invasion.
- Surgical procedures and follow-up data were analyzed for all 10 cases.
- A low survival rate was observed, with only 3 out of 10 patients surviving.
Conclusions:
- Invasive rhinocerebral aspergillosis has a poor prognosis, even with surgical intervention.
- The extent of intracranial spread significantly impacts patient survival.
- Further research into effective treatment strategies is warranted.
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