Related Experiment Video
Updated: May 17, 2026

10:26
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Inverted papilloma - an analysis of 30 cases
S K Singhal1, A K Gupta, N Panda
1Dept. of Otolaryngology, Post Graduate Institute of Medical Education and Research, 160012 Chandigarh, India.
Summary
Inverted papilloma, a benign nasal tumor, often requires repeat surgery. Radical surgical treatment offers a low recurrence rate and aids in detecting malignant changes.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Oncology
Background:
- Inverted papilloma (IP) is a benign neoplasm of the sinonasal tract.
- IPs are characterized by local aggressiveness and a propensity for recurrence.
- A significant proportion of patients present with a history of prior surgical interventions.
Purpose of the Study:
- To analyze clinical, radiological, and surgical outcomes for inverted papilloma patients.
- To evaluate the effectiveness of radical surgery in managing sinonasal inverted papillomas.
- To assess recurrence rates and the incidence of malignant transformation in treated IPs.
Main Methods:
- Retrospective analysis of 30 patients diagnosed with inverted papilloma treated between 1990-1995.
- Clinical data, radiological findings (CT scans), and surgical procedures were reviewed.
- Follow-up data regarding recurrence and malignant changes were collected.
Main Results:
- Unilateral nasal obstruction, with or without epistaxis, was the most frequent presenting symptom.
- CT scans proved valuable for delineating tumor extent and surgical planning.
- Radical surgery was performed in all cases, resulting in a 3.3% recurrence rate and 6.6% incidence of carcinomatous change.
Conclusions:
- Radical surgical excision is an effective treatment for inverted papilloma.
- Early and accurate diagnosis using CT imaging is crucial for optimal surgical planning.
- Close monitoring is essential due to the potential for recurrence and malignant transformation in inverted papillomas.
