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Prochlorperazine versus cinnarizine in cases of vertigo

A K Singh1, V N Chaturvedi

  • 1Department of Otolaryngology, MGIMS, 442102 Sevagram.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 3, 2012
PubMed

Insights

This study found that prochlorperazine and cinnarizine effectively treated vertigo, with prochlorperazine showing fewer side effects. Peripheral vertigo responded better to treatment than central vertigo.

Area of Science:

  • Otolaryngology
  • Neurology

Background:

  • Vertigo accounts for 1.82% of Ear, Nose & Throat outpatient cases.
  • Peripheral lesions cause 51.12% of vertigo, with Meniere's disease and Benign Paroxysmal Positional Vertigo (BPPV) being common.
  • Central lesions cause 48.87% of vertigo, with Vertebrobasilar Insufficiency (VBI) being the most frequent cause.

Purpose of the Study:

  • To compare the efficacy and side effects of prochlorperazine and cinnarizine in treating vertigo.
  • To assess treatment response based on vertigo origin (peripheral vs. central).

Main Methods:

  • Randomized treatment of vertigo patients with prochlorperazine ± Head Balance exercises or cinnarizine ± Head Balance exercises.
  • Evaluation of subjective improvement and side effects after 5 weeks of treatment.

Main Results:

  • Both treatments achieved high subjective improvement (100% for prochlorperazine, 97.14% for cinnarizine).
  • Prochlorperazine group reported fewer side effects (11%) compared to cinnarizine (23%), with drowsiness being more significant in the cinnarizine group.
  • Treatment response was significantly better for peripheral vertigo than central vertigo.

Conclusions:

  • Prochlorperazine and cinnarizine are effective vertigo treatments, with prochlorperazine demonstrating a better side effect profile.
  • Peripheral vertigo cases show a more favorable treatment response compared to central vertigo cases.

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