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Sinus histiocytosis with massive lymphadenopathy
Samiullah1, Hidayatullah, Nisar H Dar
1Department of ENT, JNMCH, AMU, Aligarh, 202002 Uttar Pradesh.
Summary
Sinus Histiocytosis with Massive Lymphadenopathy (SHML), a rare condition causing neck swelling, can affect extranodal sites. Alternating chemotherapy cycles showed promising results for this rare disease.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Sinus Histiocytosis with Massive Lymphadenopathy (SHML) is a rare disorder.
- It typically presents as cervical lymphadenopathy of unknown origin.
- Extranodal involvement occurs in 20-30% of cases.
Purpose of the Study:
- To evaluate the efficacy of an alternating chemotherapy regimen in patients with SHML.
- To present findings from a small series of patients treated with this novel approach.
Main Methods:
- Patients received chemotherapy with alternating cycles of ABVD and COPD regimens.
- Treatment response and side effects were monitored.
- Histological features, including emperipolesis and histiocyte morphology, were reviewed.
Main Results:
- The alternating chemotherapy regimen yielded satisfactory results in the studied patient series.
- Histological hallmarks include emperipolesis and non-cohesive histiocytes with eosinophilic cytoplasm.
- Further data on specific outcomes and adverse events are pending.
Conclusions:
- An alternating chemotherapy regimen (ABVD and COPD) may offer a viable treatment option for SHML.
- Further research is needed to establish optimal treatment protocols for this rare condition.
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