Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

The Spindle Assembly Checkpoint

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

Larynx

Larynx

The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...

Spindle Assembly

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

Spindle Assembly

Spindle Assembly

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Engineering DNA Methylation Dynamics in Plants: Strategies from Detection to Deployment.

Journal of experimental botany·2026

Same author

Epigenetic modulators in triple-negative breast cancer: epigenetic modifications and future treatment perspectives.

Epigenomics·2026

Same author

Correction: Healthcare Worker's Satisfaction Assessment for a Healthcare Adverse Event Reporting Framework and the Management Approach for Such Reporting in the Emergency Department of Rural Government Hospitals.

Cureus·2026

Same author

Primary Hepatic Leiomyosarcoma Presenting as a Multiloculated Cystic Mass: A Case Report and Review of Literature.

Cureus·2026

Same author

Genetic variants in oncogenic miRNA and 3' untranslated region of tumor suppressor genes: emerging insight into cancer genetics.

Medical oncology (Northwood, London, England)·2025

Same author

Alchemy of Fungi and AI: Response Surface Methodology and Artificial Neural Network-Based Optimization of Echinocandin B Production in Aspergillus nidulans.

Biotechnology and applied biochemistry·2025

Search research articles

Related Experiment Video

Updated: May 17, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Spindle cell sarcoma of larynx.

Sunil Samdhani¹, Anita Choudhary, Vibhuti Ranjan Mahanta

¹Department of ENT, SMS Medical College and Hospital, Jaipur.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India

|November 3, 2012

Summary

Spindle cell carcinoma of the larynx is a rare laryngeal neoplasm. Immunohistochemistry and electron microscopy confirm these are true neoplasms, with spindle cells originating from the tumor itself.

Keywords:

Spindle cell carcinoma squamous cell

Related Experiment Videos

Last Updated: May 17, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Area of Science:

Oncology
Pathology

Background:

Spindle cell carcinoma (SCC) of the larynx is a rare malignancy, accounting for only 0.6% of all laryngeal neoplasms.
These tumors predominantly affect elderly males, with an average age of 63 years.
Historically, SCC has been referred to by various terms, including pseudosarcoma, carcinosarcoma, fibromyxosarcoma, mixed sarcoma, and polypoidal sarcoma.

Purpose of the Study:

To clarify the histogenesis of laryngeal spindle cell carcinoma.
To differentiate true neoplastic spindle cells from reactive fibroblasts in laryngeal tumors.

Main Methods:

Immunohistochemistry was utilized to analyze cellular markers.
Electron microscopy was employed for ultrastructural examination of tumor cells.

Main Results:

Immunohistochemical findings support a neoplastic origin for the spindle cells.
Electron microscopy revealed ultrastructural features consistent with neoplastic cells, not reactive fibroblasts.

Conclusions:

Spindle cell carcinoma of the larynx is a distinct entity characterized by neoplastic spindle cells.
The spindle cells are an integral component of the carcinoma, not a reactive stromal response.