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Updated: May 17, 2026
06:51
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Macroglossia due to venous malformation
T S Anand1, Ritu Mittal, T B Shashidhar
1Department of Otorhinolaryngology and Head and Neck Surgery, Lady Hardinge Medical College, 110001 New Delhi, India.
Summary
A rare venous malformation of the tongue caused severe functional issues, including obstructive sleep apnea. A combined treatment of sclerotherapy, electrocautery, and radiation therapy effectively managed this extensive vascular malformation.
Area of Science:
- Vascular Surgery
- Otolaryngology
- Radiology
Background:
- Massive tongue vascular malformations present rare but significant challenges.
- These malformations can lead to severe functional impairments affecting speech, eating, and breathing.
Purpose of the Study:
- To report a rare case of extensive venous malformation of the tongue.
- To detail the functional deficits caused by the malformation.
- To describe a multimodality treatment approach.
Main Methods:
- A case of extensive tongue venous malformation was treated.
- Treatment involved a combination of sclerotherapy, electrocautery, and radiation therapy.
Main Results:
- The patient experienced obstructive sleep apnea, inability to speak and eat, and discomfort from dryness and ulceration.
- The multimodality treatment approach was employed.
Conclusions:
- Extensive tongue venous malformations are rare and cause significant functional impairment.
- A combined treatment strategy including sclerotherapy, electrocautery, and radiation therapy can be effective for managing these complex cases.
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