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Updated: May 17, 2026
08:00
Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
Published on: June 24, 2019
[Anal intraepithelial neoplasia]
Vincent de Parades1, Nadia Fathallah, Maximilien Barret
1Groupe hospitalier Paris Saint-Joseph, service de proctologie médico-chirurgicale, 75014 Paris, France. iplb@hpsj.fr
Presse Medicale (Paris, France : 1983)
|November 6, 2012
Summary
Anal intraepithelial lesions, caused by human papillomavirus, are increasing, particularly in HIV-infected individuals. High-grade lesions may progress to cancer, necessitating effective screening and prevention strategies like HPV vaccination.
Area of Science:
- Oncology
- Virology
- Dermatology
Context:
- Anal intraepithelial lesions (AIL) are linked to oncogenic human papillomavirus (HPV) infections.
- Increasing incidence and prevalence of AIL, especially in HIV-positive patients.
- High-grade AIL poses a significant risk for progression to squamous cell carcinoma.
Purpose:
- To review the current understanding of anal intraepithelial lesions.
- To discuss diagnostic and treatment modalities for AIL.
- To highlight screening and prevention strategies for AIL.
Summary:
- AIL results from chronic oncogenic HPV infection, with rising rates in HIV patients.
- High-grade lesions risk progression to squamous cell carcinoma; treatment options exist but recurrence is common.
- High-resolution anoscopy, physical exams, and cytology aid evaluation and screening; HPV vaccines may prevent AIL.
Impact:
- Early detection and management of AIL can reduce progression to anal cancer.
- Understanding AIL natural history informs patient monitoring and treatment strategies.
- HPV vaccination offers a promising preventive measure against AIL development.
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