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Large-scale Production of Recombinant RNAs on a Circular Scaffold Using a Viroid-derived System in Escherichia coli
Published on: November 30, 2018
Host endomembrane recruitment for plant RNA virus replication
Romain Grangeon1, Jun Jiang, Jean-François Laliberté
1INRS-Institut Armand Frappier, 531 Boulevard des Prairies, Laval, Québec H7V 1B7, Canada.
Current Opinion in Virology
|November 6, 2012
Summary
Plant viruses hijack cellular endomembranes, reorganizing the endoplasmic reticulum and Golgi into virus factories. These dynamic structures are crucial for viral replication and assembly within infected cells.
Area of Science:
- Plant virology
- Cell biology
- Molecular biology
Background:
- Extensive research identifies viral proteins in membrane remodeling and vesicle production.
- Limited studies investigate viral infection's impact on early secretory endomembrane architecture and dynamics.
Purpose of the Study:
- To investigate the impact of plant viral infections on the architecture and dynamics of early secretory endomembranes.
- To understand the recruitment of organelles into virus-induced structures and their functional connections.
Main Methods:
- Literature review and synthesis of recent investigations.
- Analysis of viral protein functions in membrane dynamics.
Main Results:
- Viral infections recruit endoplasmic reticulum and Golgi bodies into virus-induced perinuclear structures.
- These structures are dynamically connected to non-modified endomembranes and motile vesicles.
- These sites are implicated in viral genome replication and virion assembly.
Conclusions:
- Plant viruses significantly alter cellular endomembrane organization to create replication and assembly hubs.
- Further elucidation of molecular events driving endomembrane recruitment is needed.
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