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Updated: May 17, 2026
10:33
Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
Published on: February 23, 2014
[Clinical diagnosis of the olfactory nerve transport function]
Hideaki Shiga1, Junpei Yamamoto, Takaki Miwa
1Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University, Ishikawa, Japan. shigah@kanazawa-med.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|November 6, 2012
Summary
Nasal drug delivery to the brain shows promise via the olfactory nerve. Thallium-201 imaging can assess olfactory nerve transport in patients, aiding clinical trial candidate selection.
Area of Science:
- Neuroscience
- Pharmacology
- Medical Imaging
Context:
- Nasal drug delivery offers a potential route beyond the blood-brain barrier via olfactory nerve transport.
- Research on nasal drug delivery to the brain is established, but evaluating olfactory nerve function in patients is crucial for clinical trials.
Purpose:
- To evaluate the olfactory nerve transport function in patients with olfactory disorders.
- To determine if thallium-201 migration to the olfactory bulb can serve as an index for olfactory nerve damage.
Summary:
- Nasally administered thallium-201 migrates to the olfactory bulb in healthy volunteers.
- This migration is significantly reduced in patients with olfactory impairments due to head trauma, infections, or chronic rhinosinusitis.
- Imaging techniques like SPECT, X-ray CT, and MRI can visualize this migration.
Impact:
- This study highlights the potential of thallium-201 imaging for assessing olfactory nerve viability.
- It may aid in selecting appropriate candidates for clinical trials involving nasal drug delivery to the brain.
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