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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Pragmatic exercise intervention for people with multiple sclerosis (ExIMS trial): study protocol for a randomised

J M Saxton1, A Carter, A J Daley

  • 1School of Allied Health Professions, University of East Anglia, Norwich, UK. john.saxton@uea.ac.uk

Contemporary Clinical Trials
|November 6, 2012
PubMed
Summary

This study evaluates a 12-week exercise program with behavioral techniques to boost physical activity and health in people with multiple sclerosis (PwMS). The goal is to see if this intervention leads to sustained improvements over nine months.

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Published on: January 29, 2016

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Science

Background:

  • Exercise improves function, mobility, and quality of life for people with multiple sclerosis (PwMS).
  • The long-term effectiveness of pragmatic exercise interventions on physical activity and health outcomes in PwMS requires further investigation.
  • Dose-response relationships and cost-effectiveness of exercise interventions for PwMS are not well-established, impacting health policy decisions.

Purpose of the Study:

  • To determine if a 12-week supervised exercise program, using cognitive-behavioral techniques, improves physical activity and health outcomes in PwMS over a 9-month follow-up.
  • To explore dose-response relationships between exercise and health outcomes in PwMS with varying disease severity.
  • To evaluate the cost-effectiveness of the pragmatic exercise intervention for PwMS.

Main Methods:

  • 120 participants with multiple sclerosis (MS) and an Expanded Disability Status Score (EDSS) of 1-6.5 will be randomized (1:1) to an intervention or usual care group.
  • The intervention group will receive a 12-week pragmatic exercise therapy program incorporating cognitive-behavioral techniques.
  • Outcome measures, including physical activity, clinical/functional measures, and health-related quality of life, will be assessed at baseline, post-intervention, and 6-month follow-up.

Main Results:

  • Data collection is ongoing; results will detail changes in physical activity, functional measures, and quality of life over 9 months.
  • Analysis will explore dose-response relationships and cost-effectiveness of the intervention.
  • Findings will provide insights into the sustained impact of exercise on PwMS.

Conclusions:

  • The study aims to provide evidence on the effectiveness and cost-effectiveness of a pragmatic exercise intervention for PwMS.
  • Results will inform health policy regarding the integration of exercise therapy into routine care pathways for multiple sclerosis.
  • Understanding dose-response relationships will help tailor exercise prescriptions for individuals with MS.